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New Study Explores Dried Cranberries' Effect on Gut Health

Novel investigation evaluates the potential impact of eating dried cranberries on typical indicators of a healthy gut microbiome

CARVER, Mass., Oct. 24, 2017 Researchers from the University of Wisconsin - Madison evaluated whether one simple addition to the diet – one handful-a-day of sweetened dried cranberries – could positively influence the gut microbiome. Given the emerging knowledge that many biological functions, including immunity and disease-fighting capabilities, depend on a healthy gut microbiome, the authors of the recently published study in OMICS: A Journal of Integrative Biology, tested whether dried cranberries could make a difference. After just two weeks and with only 10 subjects, the differences were statistically insignificant but according to the researchers, were moving in the right direction. Thus, the role of dried cranberries in gut health may be worth further exploration.
"The aim of our prospective study was to determine if just one addition to the diet – a typical serving of sweetened dried cranberries – could alter a myriad of proteins and natural bacteria in the urinary proteome and fecal microbiome," explained lead author, Dr. Jess D. Reed. "Previous investigations showed that cranberry compounds influenced gut health. Similarly, our findings were positive, albeit statistically insignificant, but motivate us to continue exploring."
The team sought to determine if daily consumption of sweetened dried cranberries changed the urinary proteome and fecal microbiome with a prospective sample of 10 healthy individuals. Baseline urine and fecal samples were collected from the subjects in a fasted state (8-12 hours). The subjects then consumed one serving (42 g) of dried cranberries daily with lunch for two weeks. Urine and fecal samples were collected again the day after two weeks of dried cranberry consumption.
Researching the health benefits of cranberries is not a new phenomenon. Observational and clinical studies have raised interest in the potential health effects of cranberry consumption. In 2013, a team of scientists pulled together decades of research in a review published in Advances of Nutrition. In it, they stated that the association between cranberries and health appears to be due to the plant compounds in cranberries. Among the data reviewed were studies that evaluated the impact of cranberries on the risk of recurrent urinary tract infections, cardiovascular health and blood glucose management.1
"This trial only scratches the surface of the potential role of cranberries in whole-body health," adds study author, Chris Krueger. "These results give us another reason to delve deeper into the diverse effects cranberry compounds have on the human body."
"We are pleased that scientists are taking a fresh look at cranberries," says Terry Humfeld, executive director of The Cranberry Institute – a non-profit organization dedicated to supporting cranberry research and education. "We are especially encouraged by this study and the potential that dried cranberries could have on gut health."
A serving of dried cranberries provides 10% of the Daily Value for fiber and ½ cup is equivalent to one fruit serving according to MyPlate guidelines.2
The present research was funded by The Cranberry Institute with grant support provided by the Cranberry Marketing Committee (CMC). The CMC was established as a Federal Marketing Order in 1962 to ensure a stable, orderly supply of good quality product. The funders had no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.
For more information about The Cranberry Institute, along with the health benefits of cranberries and current scientific research, visit: www.CranberryInstitute.org.


About The Cranberry Institute (CI)
The Cranberry Institute is a not-for-profit organization founded in 1951 to further the success of cranberry growers and the industry in the Americas through health, agricultural and environmental stewardship research as well as cranberry promotion and education. The Cranberry Institute is funded voluntarily by Supporting Members that handle, process, and sell cranberries. Supporting Members are represented in national and international regulatory matters and research efforts are done on their behalf.


About the Cranberry Marketing Committee (CMC) 

The CMC was established as a Federal Marketing Order in 1962 to ensure a stable, orderly supply of good quality product. Authority for its actions are provided under Chapter IX, Title 7, Code of Federal Regulations, referred to as the Federal Cranberry Marketing Order, which is part of the Agricultural Marketing Agreement Act of 1937, as amended. This Act specifies cranberries as a commodity that may be covered, regulations that may be issued, and guidelines for administering the programs, and privileges and limitations granted by Congress. For more information about the CMC, visit uscranberries.com. Follow at twitter.com/uscranberries and facebook.com/uscranberries.


References
1. Blumberg JB, Terri A. Camesano TA, Cassidy A, Kris-Etherton P, Howell A, Manach C, Ostertag LM, Sies H, Skulas-Ray A, Vita J. Cranberries and their bioactive constituents in human health. Adv Nutr. 2013;4:1–15.
2. United States Department of Agriculture. Choose MyPlate. Tips to help you eat fruits. http://www.choosemyplate.gov/food-groups/fruits-tips.html. Accessed:May 24, 2012.

 

New Investigation Advises Doctors to Recommend Cranberry Products as First Line of Defense Against Repeated Urinary Tract Infections (UTIs) 
Comprehensive meta-analysis affirms cranberries’ role in promoting a healthy urinary tract.

CARVER, Mass., September 19, 2017 – A thorough review of dozens of studies led scientists to conclude that healthcare professionals should be telling their patients to have cranberry products as a first step in reducing recurrent UTIs. The comprehensive meta-analysis and assessment of human clinical trials, published in the official journal of the American Urological Association, The Journal of Urology®, assures practitioners and their patients that cranberry products are a low cost, low risk and effective way to help prevent recurrent UTIs.1

To answer the question, “Can Cranberries Contribute to Reduce the Incidence of Urinary Tract Infections?” a total of 28 studies showing results from nearly 5,000 patients were considered. Authors found a statistically significant risk reduction in repeat UTIs overall, but not significant for any particular subgroup. However, patients with recurrent UTIs who ingested cranberry products and had undergone gynecological surgery, experienced a significant reduction in UTIs.

“Our investigation supports that cranberry products can be a powerful tool to fight off frequent UTIs,” explains lead author, Dr. Ângelo Luís. “While recommendations for dosage and duration of treatment require further study, the efficacy of the medicinal properties of cranberry products has been well-established.”

The review explains that the medicinal properties of cranberries may be attributed to their unique polyphenol, proanthocyanidins – or PACs, for short. Their ability to keep infection-causing bacteria from sticking to the urinary tract walls may be the major reason for their effectiveness in limiting infection growth and recurrence.

According to the authors, scientists and practitioners continue to explore the use of alternative therapies in the prevention of common infections as part of the global movement to reduce antibiotic use and resistance. It is estimated that one third of women in the United States will get a UTI by the age of 24.2

“Findings like this,” adds Dr. Luis, “give practitioners a viable, inexpensive, non-antibiotic option to help patients reduce the recurrence of an uncomfortable and potentially debilitating infection.”

 “As one of the oldest alternative therapies and U.S.-born berries, independent research such as this not only provides public health benefits, it revitalizes the enthusiasm for cranberry products year-round. The industry appreciates the efforts of these researchers and takes pride in the healthy attributes that cranberry products provide to consumers around the world,” comments Terry Humfeld, executive director of the non-profit research and education-focused organization, The Cranberry Institute.

This review was funded by Universidade da Beira Interior and bank Santander/Totta protocol post-doctoral research fellowship BIPD/ICI-FC-BST-UBI 2016 (ÂL).

About the Cranberry Institute
The Cranberry Institute is a not-for-profit organization founded in 1951 to further the success of cranberry growers and the industry in the Americas through health, agricultural and environmental stewardship research as well as cranberry promotion and education. The Cranberry Institute is funded voluntarily by Supporting Members that handle, process, and sell cranberries. Supporting Members are represented in national and international regulatory matters and research efforts are done on their behalf. For more information about the Cranberry Institute, along with the health benefits of cranberries and current scientific research, visit www.CranberryInstitute.org.

References:

  1. Luis A, Domingues F and Pereira, L. Can cranberries contribute to reduce the incidence of urinary tract infections? A systematic review with meta-analysis and trial sequential analysis of clinical trials. J Urol 2017; 614-21.
  2. Foxman B, Barlow R, D'Arcy H, Gillespie B and Sobel JD. Urinary tract infection: self-reported incidence and associated costs. Ann Epidemiol 2000; 10:509–515.

 

Contact
Terry Humfeld
The Cranberry Institute
(302)-355-5970
thumfeld@cranberryinstitute.org

Stephanie Baber
Pollock Communications
Email: sbaber@pollock-pr.com
Phone: (212) 941-1414