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Cranberry juice induces nitric oxide-dependent vasodilation in vitro and its infusion transiently reduces blood pressure in anesthetized rats

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Authors
Maher MA, Mataczynski H, Stefaniak HM and Wilson T
Journal
J Med Food 3(3):141-7
Abstract

ABSTRACT Red wine vasodilates rat aortae, an effect attributed to polyphenolic compounds. Cranberry juice (CBJ) is also rich in polyphenols. We determined that CBJ has vasorelaxing properties similar to those of red wine. Rat aortic rings cleaned in Krebs buffer, pH 7.4, bubbled with 95% O(2) and 5% CO(2) were recovered for 30 minutes at 37 degrees C under 2.0 g tension. After phenylephrine (PE, 100 mumol/L) contraction, acetylcholine (3 mumol/L)-induced relaxation of intact vessel was significantly higher than in denuded vessels (59.1 +/- 0.27% versus 10.1 +/- 0.09% of the maximal PE contraction; P <.003 after="" a="" second="" pe="" contraction="" dilution="" of="" cbj="" was="" added.="" intact="" rings="" were="" vasodilated="" by="" with="" relaxation="" compared="" to="" denuded="" addition="" l-name="" reversed="" cbj-induced="" vasorelaxation="" in="" vessels="" g="" subsequent="" l-arginine="" resulted="" return="" vasodilation="" vessels.="" additionally="" infusion="" at="" estimated="" blood="" volume="" reduction="" mean="" arterial="" pressure="" anesthetized="" rats.="" this="" study="" suggests="" that="" like="" red="" wine="" has="" the="" capacity="" exert="" vitro="" and="" vivo="" vasodilatory="" effects.="">