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Effects of cranberry consumption on features of the metabolic syndrome: a systematic review and meta-analysis of randomized control trials

Hormoznejad, R., Mansoori, A., Hosseini, S. A., Zilaee, M., Asadi, M., Fathi, M., Kiany, F.
Nutrition & Food Science 2021. 51(6):1006-1016.

Purpose: The purpose of this paper with meta-analysis is to clarify the effects of cranberry consumption on features of the metabolic syndrome of interest of all relevant randomized controlled trials (RCTs). Design/methodology/approach: A systematic literature search was conducted on ISI web of science, PubMed, Embase, the Cochrane library and Google Scholar databases, to include trials published up to March 2019. Weighted mean differences (WMD) were calculated from a random or fixed-effects models. Between-study heterogeneity was assessed by Cochrane's test and I2 index. Findings: Ten RCTs were included in this review which involving a total of 371 subjects. Our meta-analysis showed that cranberry consumption had beneficial effects on waist circumference (WMD -0.49, 95% CI -0.96 to -0.036; p = 0.034). No significant effect of cranberry consumption on fasting blood glucose, high-density lipoprotein cholesterol, triglycerides and blood pressure was found in this meta-analysis. Originality/value: To the best of the authors' knowledge, this is the first systematic review with meta-analysis of RCTs that investigate the effect of cranberry consumption on features of the metabolic syndrome.