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A high molecular mass constituent of cranberry juice inhibits helicobacter pylori adhesion to human gastric mucus.

Posted
Authors
Burger O, Ofek I, Tabak M, Weiss EI, Sharon N, Neeman I
Journal
FEMS Immunol Med Microbiol 29(4):295-301
Abstract

Because previous studies have shown that a high molecular mass constituent of cranberry juice inhibited adhesion of Escherichia coli to epithelial cells and coaggregation of oral bacteria, we have examined its effect on the adhesion of Helicobacter pylori to immobilized human mucus and to erythrocytes. We employed three strains of H. pylori all of which bound to the mucus and agglutinated human erythrocytes via a sialic acid-specific adhesin. The results showed that a high molecular mass constituent derived from cranberry juice inhibits the sialic acid-specific adhesion of H. pylori to human gastric mucus and to human erythrocytes.