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Inhibitory effects of cranberry polyphenols on formation and acidogenicity of Streptococcus mutans biofilms

Posted: 
December 17, 2010
Authors: 
Duarte S, Gregoire S, Singh AP, Vorsa N, Schaich K, Bowen WH, Koo H
Journal: 
FEMS Microbiol Lett 257(1):50-56
Abstract: 

Cranberry fruit is a rich source of polyphenols, and has shown biological activities against Streptococcus mutans. In the present study, we examined the influence of extracts of flavonols (FLAV), anthocyanins (A) and proanthocyanidins (PAC) from cranberry on virulence factors involved in Streptococcus mutans biofilm development and acidogenicity. PAC and FLAV, alone or in combination, inhibited the surface-adsorbed glucosyltransferases and F-ATPases activities, and the acid production by S. mutans cells. Furthermore, biofilm development and acidogenicity were significantly affected by topical applications of PAC and FLAV (P