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Cardiovascular Health & Anti-inflammatory Benefits

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Comparison of urinary cytokines after ingestion of cranberry juice cocktail in pregnant subjects: a pilot study.

Posted: 
October 31, 2010
Authors: 
Wing DA, Rumney PJ, Leu SY, Zaldivar F
Journal: 
Am J Perinatol 27(2):137-42
Abstract: 

Our objective was to evaluate urinary cytokine excretion after daily cranberry or placebo exposure in pregnant women. Four-hour urine samples were collected from 27 pregnant women subjects who were randomized to cranberry juice cocktail or placebo in three treatment arms: A: Cranberry (C) two times daily (C, C; n = 10 pregnant); B: cranberry in the AM, then placebo (P) in the PM (C, P; n = 9 pregnant); and C: placebo two times daily (P, P; n = 8 pregnant). Urinary cytokines were measured using commercially available kits. There was a statistically significant difference in interleukin (IL)-6 of the urinary cytokines between the multiple daily cranberry dosing group (group A [C, C]): median, 3.16 (range, 0.01 to 7.34) and the placebo group (group C [P, P]): 9.32 (0.53 to 29.61 pg/mL; p = 0.038, Kruskal-Wallis test). We concluded that a difference in IL-6 was found in the multiple daily cranberry dosing groups compared with placebo. Lack of differences based on treatment allocation in the other cytokines may be due to beta error. Further studies are planned to evaluate these assays for the assessment of clinical effect.

Cranberry juice induces nitric oxide-dependent vasodilation in vitro and its infusion transiently reduces blood pressure in anesthetized rats

Posted: 
October 31, 2010
Authors: 
Maher MA, Mataczynski H, Stefaniak HM and Wilson T
Journal: 
J Med Food 3(3):141-7
Abstract: 

ABSTRACT Red wine vasodilates rat aortae, an effect attributed to polyphenolic compounds. Cranberry juice (CBJ) is also rich in polyphenols. We determined that CBJ has vasorelaxing properties similar to those of red wine. Rat aortic rings cleaned in Krebs buffer, pH 7.4, bubbled with 95% O(2) and 5% CO(2) were recovered for 30 minutes at 37 degrees C under 2.0 g tension. After phenylephrine (PE, 100 mumol/L) contraction, acetylcholine (3 mumol/L)-induced relaxation of intact vessel was significantly higher than in denuded vessels (59.1 +/- 0.27% versus 10.1 +/- 0.09% of the maximal PE contraction; P <.003 after="" a="" second="" pe="" contraction="" dilution="" of="" cbj="" was="" added.="" intact="" rings="" were="" vasodilated="" by="" with="" relaxation="" compared="" to="" denuded="" addition="" l-name="" reversed="" cbj-induced="" vasorelaxation="" in="" vessels="" g="" subsequent="" l-arginine="" resulted="" return="" vasodilation="" vessels.="" additionally="" infusion="" at="" estimated="" blood="" volume="" reduction="" mean="" arterial="" pressure="" anesthetized="" rats.="" this="" study="" suggests="" that="" like="" red="" wine="" has="" the="" capacity="" exert="" vitro="" and="" vivo="" vasodilatory="" effects.="">

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